
The Top 5 Microdosing Protocols (And Which One Is Right for You)
Whether you’re new to microdosing or refining your routine, choosing the right schedule is key to maximizing benefits. Let’s break down the top five most popular microdosing protocols and how to decide which is best for your lifestyle.
1. The Fadiman Protocol
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Schedule: Dose on Day 1, then take two days off
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Why it works: Prevents tolerance buildup and helps track effects clearly
2. The Stamets Stack
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Schedule: 4 days on, 3 days off
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Added Bonus: Combines psilocybin with Lion’s Mane and Niacin
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Goal: Supports neurogenesis and brain health
3. Microdosing Every Third Day
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Schedule: Dose, then skip two days
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Benefit: Simplicity and long-term sustainability
4. Weekdays Only
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Schedule: Monday through Friday
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Ideal for: Professionals using microdosing for focus and productivity
5. Intuitive Dosing
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Schedule: No set schedule—dose as needed
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Best for: Experienced microdosers tuned into their bodies